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Engineered enzymes enable greener one-pot amide synthesis for drug manufacturing

A single type of chemical structure that shows up again and again in modern medicine is the amide bond that links a carbonyl group (C=O) to a nitrogen atom. They're so ubiquitous that 117 of the top ...
EurekAlert!

A “new-to-nature” enzyme for amide synthesis: How PKU scientists repurposed an everyday enzyme to build life-saving drugs

Takeaway 1: Turning Acid-Makers into Amide-Builders The core breakthrough involves the molecular hijacking of Aldehyde Dehydrogenases (ALDH), a massive superfamily of enzymes found throughout the ...
Phys.org

Toward a better understanding of structure-metabolism relationships in human aldehyde oxidase (Update)

DOI: 10.1073/pnas.1618881114 Abstract Aldehyde oxidase (AOX) is a metabolic enzyme catalyzing the oxidation of aldehyde and aza-aromatic compounds and the hydrolysis of amides, moieties frequently ...
C&EN

Chemists revive an old route to amides, making it safer

Chemists have been using the Schmidt reaction, which transforms aldehydes and ketones into amides, for nearly 100 years. But the reaction has a downside that prevents it from being widely used: it ...