Cyclic GMP-AMP synthase (cGAS) functions as a foreign DNA sensor, triggering an immune response to pathogens by activating the STING (stimulator of interferon genes) receptor. Shortly after its ...
The cGAS–STING pathway is part of the innate immune system and is involved in the detection of cytosolic deoxyribonucleic acid (DNA). Post-detection, this pathway triggers the defense mechanisms that ...
cGAS-STING signaling exerts antitumor functions in cancer cells in an autonomous and non-autonomous manner. On the one hand, OIS secretes SASP in response to oncogenic stimuli to prevent cell ...
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