Cyclooxygenases (COX-1 and COX-2) lie at the heart of the inflammatory cascade, catalysing the conversion of arachidonic acid into bioactive prostaglandins that mediate pain, fever and vascular ...
COX-2 plays a pivotal role in ferroptosis during the progression of chronic liver disease, as it downregulates the Nrf2 signaling pathway, exacerbating ferroptosis, which is characterized by ferrous ...
Cyclooxygenase-2 (COX-2) is a key inducible enzyme in the renal prostanoid biosynthesis pathway, converting arachidonic acid into prostaglandin H2, the precursor to various prostaglandins central to ...
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