In a recent paper in ACS Central Science, researchers report a strategy for targeting covalent modifications to specific sites on proteins. The modifier molecules use an antibody to target a protein ...
Allyl isothiocyanate, the pungent principle of wasabi and other mustard oils, produces pain by activating TRPA1, an excitatory ion channel on sensory nerve endings. Isothiocyanates are ...
Chemists use activity-based protein profiling (ABPP) to look for functional enzymes with specific activities, sometimes in hopes of finding leads for drug development. They search for these enzymes ...
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