A new gene-editing technique called PERT offers a potential single-tool solution for numerous genetic disorders caused by nonsense mutations. This method, described in Nature, instructs cells to read ...

Although previously thought to be neutral, research in yeast suggests that synonymous point mutations may have strongly nonneutral effects. A group of researchers from the University of Michigan (MI, ...

For example, there is a synonymous mutation in the chloride transmembrane cystic fibrosis transmembrane conductance regulator (CFTR) that slows down CFTR production and folding because it interacts ...

A new gene-editing technique known as PERT has shown the ability to correct a wide range of disorders caused by “nonsense” mutations, including forms that interfere with haemoglobin production. The ...