Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

RAB7A plays a central role in the final stages of autophagy, facilitating autophagosome-lysosome fusion, lysosome positioning, and cargo degradation. Its activation by guanine nucleotide exchange ...

How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open ...

Researcher Ankita Dhar and facility manager M. Jason de la Cruz at work in MSK's cryo-electron microscopy facility, where MSK's new fourth-generation Krios microscope (far left, behind the glass) ...

One of the most exciting advances in cancer treatments in the past decade is the development of T cell immunotherapies, in which a patient's own immune system is trained to recognize and attack ...

Cryogenic electron microscopy showed for the first time that large RNA complexes can assemble without the help of proteins, expanding our understanding of RNA folding and function. Ribonucleic acid ...

In order to expand access to cutting-edge research technology, the University of California, Santa Cruz, is welcoming institutions in the United States and abroad to use its powerful ...

Structural biology is used to understand the three-dimensional shape of biological molecules and how their shape enables them to function both inside and outside of cells. Furthermore, the ...