Nature

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

Integrins are transmembrane adhesion receptors that coordinate cellular responses with the extracellular environment. Integrin function is especially important in neutrophils and macrophages, key ...
Nature

Computational design of an integrin I domain stabilized in the open high affinity conformation

We have taken a computational approach to design mutations that stabilize a large protein domain of ∼200 residues in two alternative conformations. Mutations in the hydrophobic core of the αMβ2 ...
JSTOR Daily

Integrin α Subunit Ratios, Cytoplasmic Domains, and Growth Factor Synergy Regulate Muscle Proliferation and Differentiation

The role of integrins in muscle differentiation was addressed by ectopic expression of integrin α subunits in primary quail skeletal muscle, a culture system particularly amenable to efficient ...
Fred Hutch

Insights on the exapted inserted domain in integrin

Protein evolution occurs slowly via small incremental mutations—usually. However, dramatic changes can happen: for instance, a fragment of one protein getting copied into the middle of another. While ...
JSTOR Daily

Stabilizing the Integrin αM Inserted Domain in Alternative Conformations with a Range of Engineered Disulfide Bonds

Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 26 (Dec. 24, 2002), pp. 16737-16741 (5 pages) Conformational movement of the C-terminal α7 helix in the ...