One of the first intracellular kinases to be explicated as a protooncogene was c-Src, an upstream mediator of both the PI 3-K and MAPK pathways. The amplified c-Src activity has been implicated in ...

Insulin binding to Golgi and plasmalemma fractions from the liver of obese (ob/ob and db/db) and lean control mice was studied. The specificity of binding in Golgi fractions (Golgi vesicles and Golgi ...

For example, Kaufman et al 60 used a Boolean formalism to explore how kinases remain active, even after the antigen unbinds from the TCR, linking the timing of antigen binding and intracellular signal ...

Cellular signaling pathways control the proliferation, differentiation, survival, and migration of normal cells. But, dysregulation of these cells can cause tumors to form and grow. The overexpression ...