The process of bone healing is not simply 'soft tissue becoming hard.' It is a regenerative process where multiple mechanisms ...

A literature search was carried out using PubMed and the keywords—osteogenesis; VEGF; endochondral ossification; and intramembranous ossification. Articles that only described the effect of VEGF on ...

Musculoskeletal disorders are a primary cause of disability worldwide, especially in aging societies like Japan. As individuals age, reductions in muscle mass and physical activity weaken the body's ...

For patients with thoracic ossification of the posterior longitudinal ligament (T-OPLL), surgical treatment is effective for improving neurological function, quality of life (QoL), and pain management ...

We have identified a macrophage population "Mrep" that plays an essential role in muscle repair. However, in Fibrodysplasia ossificans progressiva (FOP), Mrep functions as a pathogenic cell that ...