With the aid of X-ray crystallography, researchers at the University of Michigan have revealed the structures of two closely related enzymes that play essential roles in the body's ability to ...

A small molecule (shown here in pink) with the ability to increase 'good' (HDL) cholesterol in animal models binds to the membrane-binding domain of lecithin:cholesterol acyltransferase (LCAT; shown ...

today announced that MedImmune, its global biologics research and development unit, has acquired AlphaCore Pharma, an Ann Arbor, Michigan-based biotechnology company focused on the development of ...

Download the latest edition Through proteomics analysis, the research team screened and identified the hepatic factor LCAT, the liver-bone axis regulator. As a cholesterol transferring enzyme, LCAT is ...

Cholesterol transport underpins the development and prevention of cardiovascular disease through a finely tuned network of lipid carriers, enzymes and cellular transporters. Low-density lipoproteins ...