Researchers have revealed the structure and function of a previously unknown lysosome transporter. The groups of Christian Löw (CSSB, EMBL Hamburg), Markus Damme (Christian-Albrechts-University Kiel), ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes. Lysosomes ...

Our cells have their own internal "garbage collection" system that gathers up everything that is defective, worn out or ...

An international research team from Bielefeld University and the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) has uncovered a previously unknown regulatory mechanism in human cells.

Lysosomes are the control centers for the metabolism of cells and tissues, including the brain. They break down defective proteins and other macromolecules into their basic building blocks. At the ...

Lysosomes, the cell's recycling hubs, are best known for their role in a group of rare inherited conditions called lysosomal storage disorders, where harmful molecules build up inside these ...

As blood stem cells age, their lysosomes become overactive and damaged, triggering inflammation and weakening the body’s ability to regenerate healthy blood and immune cells. By calming this cellular ...

The retromer complex controls protein sorting, transport, and disposal via the endolysosome system. It goes awry in neurodegenerative diseases, but how so remains unclear. Metabolism breaks down in ...

A groundbreaking anticancer treatment technology that selectively targets cancer cell lysosomes and overcomes drug resistance has been developed by Professor Ja-Hyoung Ryu and his research team in the ...