In a study published in Science Advances, University of Alabama at Birmingham researchers led by Kasey Brida and Jeremy Day, Ph.D., report that the secreted glycoprotein reelin is a marker for those ...

Understanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson’s disease (PD) given the architecture of the basal ganglia. Here, we developed a custom ...

A research team has made a significant breakthrough in understanding the complex neural circuitry underlying reward and addiction by identifying 34 distinct subtypes of medium spiny neurons (MSNs) in ...

The extent to which newly generated medium spiny neurons integrate into the brain's networks has remained unclear. The new research, conducted in a mouse model of Huntington's disease, demonstrates ...

Cocaine, a drug of abuse, activates just a portion—10% to 20%—of the neurons in the brain's nucleus accumbens, a critical region linked to motivation and addiction. Though small in numbers, this ...

A new study published in the journal Cell Reports reveals that the adult brain can generate new neurons that integrate into key motor circuits—an insight that challenges long-held beliefs about adult ...

BIRMINGHAM, Ala. – Cocaine, a drug of abuse, activates just a portion — 10 to 20 percent — of the neurons in the brain’s nucleus accumbens, a critical region linked to motivation and addiction. Though ...