Automated, detergent-free purification preserves native membrane protein structure while supporting more reliable target ...

Membrane proteins are important targets in modern drug research because they are involved in critical cellular processes such as signal transduction, ion transport, and molecular recognition, and they ...

Membrane proteins are ubiquitous cellular components that are responsible for a wide array of cellular and molecular activities, including drug metabolism, lipid shuttling, and antibiotic resistance.

G protein-coupled receptors (GPCRs) are targets for about 35 percent of approved drugs, but a large proportion of GPCRs remain structurally uncharacterized. Producing stable and functional receptor ...

Researcher Ljubica Mihaljevic works on de novo-designed proteins for membrane protein solubilization and structure determination at a lab bench in the UW Medicine Institute for Protein Design in ...