Irish Medical Times

Immune trigger may play key role in MS progression

A key immune system switch may play a key role in the development of multiple sclerosis (MS), an Irish study has found. In a ...
Trinity College Dublin

Key immune trigger identified that may be a central player in MS progression

Researchers believe this study further highlights that a key immune system switch warrants full investigation in MS and may ...

AC Immune Initiates Phase 1 Clinical Trial of NLRP3 Inhibitor

AC Immune Initiates Phase 1 Clinical Trial of NLRP3 Inhibitor ACI-19764 is an orally available highly brain-penetrant small molecule NLRP3 ...
BioWorld

Brain penetration profile of Nodthera’s NLRP3 inflammasome inhibitor described

Aberrant NLRP3 inflammasome activation is at the root of a wide number of conditions, from heart, gastrointestinal, kidney or liver disorders to neuroinflammatory diseases such as Parkinson’s disease ...
manilatimes

Insilico Medicine Nominates ISM5059, the Peripheral-restricted NLRP3 Inhibitor as Preclinical Candidate, for the Treatment of Multiple Inflammatory and Metabolism Indications

NLRP3 is a validated anti-inflammatory target that mediates the release of proinflammatory cytokines IL-1β and IL-18, and ISM5059 targets systemic inflammatory conditions by targeting NLRP3 and ...