Proteins perform their many different functions via physical interactions with other molecules, in particular, small molecules present in cells, such as metabolites. These interactions occur on ...

Figure 1. This figure depicts the four categories of protein druggability target screening tools discussed in this section, which include structure-based methods, sequence-based methods, machine ...

Imagine, says Milenko Cicmil, a crunched-up piece of paper. The surface of the ball is riddled with creases, folds, and pockets. A protein is like a more complex version of that crunched paper ball ...

When Milenko Cicmil, PhD, first heard about the technology underlying Tasca Therapeutics, a newly-minted small molecular inhibitor company, he was intrigued. The privately-held company, which launched ...