How can the multifunctional factor Sonic Hedgehog (SHH) elicit specific responses from its target cells? A study now pinpoints proteoglycans as crucial anchors and modulators of SHH signaling, ...

LA JOLLA, CA—Scientists at Scripps Research have developed a set of methods for the closer study of one of the least-accessible, least-understood players in biology: protein-sugar conjugates called ...

Proteoglycans—molecules consisting of a core protein with multiple sugar chains—are so complex that researchers usually study the protein and sugar components separately, which makes it difficult to ...

In a recent study published in IScience, a team of researchers from the United States examined the impact of heparan-sulfate-modified proteoglycans (HSPGs) on Alzheimer's disease-associated pathways ...