Learn more about peptideins and how researchers are shedding light on the dark proteome — the mysterious and largely ...

For the neurons in the brain to work smoothly and be able to process information, the central nervous system needs a strictly regulated environment. This is maintained by the blood–brain barrier, ...

Missense variants remain a challenge in genetic interpretation due to their subtle and context-dependent effects. While current prediction models perform well in known disease genes, generalizability ...

Researchers studying the dark proteome are investigating proteins that lack clear structures or known functions. Experts, ...

Electrical synapses containing Connexin 36 (Cx36) represent the main means for direct electrical communication among neurons in the mammalian nervous system. However, little is kn ...

The official catalog of human proteins is far from complete. By analyzing billions of data points, an international team added 1,785 new entries to the human proteome. The work was led by the Princess ...

Scientists thought they had a working map of the human proteome. Some stretches of DNA made useful proteins, while a murkier, “dark” region seemed mostly inactive or irrelevant. Turns out their map ...

A research team led by scientists at the Princess Máxima Center for Pediatric Oncology, the University of Michigan Medical School, EMBL European Bioinformatics Institute, and the Institute for Systems ...

More than 64,000 proteomics datasets have now flowed through ProteomeXchange, and the consortium’s latest update shows how smarter standards, stronger reuse tools, and AI-ready resources are reshaping ...

Researchers and physicians alike are interested in identifying biomarkers from minimally invasive samples like blood to aid in disease detection and monitoring. However, so far, most targets observed ...