When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...

At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

Researchers have identified an alternate method to study changes during the DNA replication process in lab settings using genetically modified yeast. The new approach offers a clearer window than ...

Researchers have gained a clearer insight into how common alterations to the structure of DNA affect the process of DNA replication. These structural changes can put a stop to replication, causing ...

Retrotransposons are sequences of DNA in animal genomes that can replicate and reinsert themselves back into the genome. Experiments in flies and other model systems reveal that retrotransposons ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Every time a cell divides, it must copy roughly three billion letters of DNA with near-perfect fidelity. That copying process, DNA replication, is among the most demanding operations a cell performs, ...

It has been discovered that there are multiple types of DNA sites prone to breakage, beyond those previously known. This was announced by RIKEN, Kobe University, and JST. By examining cells one by one ...

An elegant collaboration between researchers in the UK's two core-funded Medical Research Council Research Institutes, the Laboratory of Medical Sciences (LMS) in London and the Laboratory of ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...