Alzheimer’s researchers at UVA have discovered the harmful effects of tau proteins on brain cells and the damage done to their essential operating instructions. The finding, referred to as untreatable ...

Alzheimer's disease is a neurodegenerative disease characterized by a progressive decline in mental functions and memory loss. Along with frontotemporal dementia and some other neurodegenerative ...

Tauopathies are a group of neurodegenerative diseases associated with aggregated tau proteins. These diseases typically progress over the years, and their symptoms are linked to neurological ...

Accumulation of pathologic tau protein plays a pivotal role in the neurodegeneration of Alzheimer's disease (AD) and many other tauopathies. Thus, amelioration of pathological tau aggregates in the ...

Under normal circumstances, tau protein is part of the brain’s infrastructure, important for stabilizing neurons into their proper shapes. But sometimes tau gets knotted up into tangles and turns ...

In tauopathies, scientists tend to focus on neuronal tau. They track its pathology and blame it for dysfunctional microglia. Now, researchers led by Celeste Karch at Washington University, St. Louis, ...

Newly reported research headed by a team at the Perelman School of Medicine at the University of Pennsylvania points to a potential gene therapy approach to neurodegenerative disorders characterized ...

Results of a cross-species genetic screen published in the journal Neuron “Evolutionarily conserved regulators of tau identify targets for new therapies” have identified 11 genes that regulate levels ...

Tauopathies are classified by which tau isoform forms fibrils—those with three microtubule-binding domain repeats (3R), those with four (4R), or those with both. What drives one isoform to aggregate ...

This study is led by Prof. Jian-Zhi Wang (Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology), Prof. Jie Zheng (Department of Neurobiology, School of ...