Heat Shock Factor 1 (HSF1) is a pivotal transcription factor that orchestrates the cellular response to proteotoxic and various other forms of stress. By regulating a comprehensive transcriptional ...

Deletion of hsf5 in mice results in the impaired development of testis (left), and the absence of spermatids and spermatozoa (right), which leads to the failure of sperm formation. Kumamoto University ...

Increased expression levels of human telomerase reverse transcriptase (hTERT) mRNA correlates with poor prognosis in resected non-small cell lung cancer (NSCLC) patients ...

Heat shock factors (HSFs) are the main transcriptional regulators of the evolutionarily conserved heat shock response. Beyond cell stress, several studies have demonstrated that HSFs also contribute ...

Progress and perspectives on the biology of heat shock proteins and molecular chaperones / R.I. Morimoto, A. Tissieres, C. Georgopoulos -- Cytosolic hsp70s of Saccharomyces cerevisiae: roles in ...

Biological cells undergo a process known as “heat stress response” when exposed to excessively high temperatures. Heat stress triggers a cascade of signaling mechanisms to produce a variety of heat ...

Rising temperatures disrupt human cellular stability by impairing proteostasis, altering mitochondrial function, reprogramming gene expression, and reshaping immune responses, ultimately shifting ...