Aptamer with protein (+) and without protein (-) is loaded into wells in a gel and moves down the column lanes. If target is present, they bind and travel more slowly, due to the charge on the aptamer and …

核酸适配体（Aptamer）是一类通过指数富集的配体系统进化技术（SELEX）筛选获得的短单链DNA或RNA寡核苷酸。 其通过特定三维构象高特异性结合靶标分子，具有稳定性强、合成成本低及非免疫 …

Jun 19, 2025 · Abstract Aptamer therapeutics represent a class of target-based therapies that leverage their high specificity and affinity for diverse molecular targets. As single-stranded DNA or RNA …

Aug 23, 2025 · The unique three-dimensional structure that an aptamer adopts allows it to precisely fit into or interact with specific pockets or surfaces on its target molecule. This shape complementarity …

核酸适配体（Aptamer） 通常是通过指数富集的配体系统进化技术（SELEX）筛选得到一类单链DNA或RNA。 它是一类短的单链寡核苷酸序列，可形成部分互补配对的 二级结构，这些结构是其发挥生物 …

Dec 24, 2024 · The Sgc8 aptamer is currently in clinical trials for the staging of bladder cancer. Sgc8 is an unmodified 88-nt DNA aptamer that binds protein tyrosine kinase-7 [11, 84].

In this review, we discuss the aptamer discovery process as well as aptamer applications to biosensors and separations. In the discovery section, we describe the major steps of the library selection …

Mar 2, 2024 · In 2004, the first aptamer therapeutic, Macugen (Pegaptanib) was approved by the FDA, which is presently the only aptamer approved by the US FDA. It is effective as an anti-angiogenic …

Nov 20, 2025 · 适体 （英语： aptamer，源自 拉丁语： aptus “适合”和 希腊语： μέρος “部位”）是指与特定的目标分子结合的 寡聚核酸 或是 肽 链。 适体常常从大量的随机 序列 被挑选出来，但自然的适体 …

Nov 27, 2025 · In a recent ScienceDirect publication, researchers have developed aptamer stains carrying photo-cleavable linkers and multiple fluorescent tags that achieve femtomolar sensitivity and …