A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. N -acetylneuraminic acid, NANA) linked on the sugar chain.

In this review, we will summarize ganglioside functions that are crucial to maintain brain health, we will review changes in ganglioside levels that occur in major neurological conditions and we will discuss …

Altered ganglioside levels or profiles are associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, where they may contribute to neuronal dysfunction and …

Ganglioside lactones, where the sialic acids are linked together through inner ester bonds, have been detected as minor components in brain tissues, where lactonization occurs at the plasma membrane.

The diversity of ganglioside species is reflected in their structural complexity, with GM1, GD1a, GD1b, and GT1b representing the four most abundant complex gangliosides in the nervous system.

Understanding the regulatory mechanisms governing ganglioside biosynthesis is essential for elucidating their roles in health and disease and may provide insights into therapeutic interventions …

Aug 13, 2025 · Rare subjects with congenital disorders of ganglioside biosynthesis suffer severe and broad multi-system deficits. Changes in ganglioside expression are characteristic of cancer and …

Jun 18, 2024 · They contribute to cell regulation by interacting with proteins in their own membranes (cis) or their extracellular milieu (trans). As amphipathic membrane constituents, gangliosides …

Jul 31, 2025 · In this review, we summarize the current understanding of the molecular pathogenesis of congenital ganglioside biosynthesis disorders, integrating data from genetically engineered mouse …

Sep 17, 2025 · Given that depletion of cellular gangliosides—either pharmacologically (Genz-123346) or genetically (CRISPR-Cas9 KO of B4galnt1)—reduced ganglioside content in secreted EVs, …