Mar 16, 2026 · In this issue of the JCI, Köcher et al. have demonstrated that ERG overexpression in human prostate cancer cells rewired DNA double-strand break repair toward a poly (ADP-ribose) …

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Mitochondrial dysfunction fuels vascular inflammation and atherosclerosis. Mitochondrial calcium uptake 1 (MICU1) maintains mitochondrial Ca 2+ homeostasis. However, the role of MICU1 in vascular …

Pseudoxanthoma Elasticum (PXE) is a rare disease caused by loss of function of the gene Abcc6 and characterized by ectopic calcification of multiple tissues, but the physiological reasons underlying …

Apr 1, 2026 · Konishi et al. report a unique thick microtubule bundle organization that is required to generate expansive and thin cell morphology during alveolar type 2 cell differentiation into alveolar …

Feb 16, 2026 · Glucagon-like peptide-1 receptor agonists (GLP-1RAs), established therapies for type 2 diabetes and obesity, are increasingly recognized for their potential in neurodegenerative diseases. …

Mar 25, 2025 · Tumor-associated macrophages (TAMs) are the most prominent immune cell population in the glioblastoma (GBM) tumor microenvironment and play critical roles in promoting tumor …

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