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Most people who stop metformin do not stop because it failed. They stop because of the first two weeks. Metformin works mainly on your liver, but a large amount of the drug stays in your intestine and sits there in high concentration. That is where the nausea, the cramping and the diarrhoea come from. It is a local effect, not the drug poisoning you, which is why the fixes are practical. Taking it with food slows the exposure. Starting low and increasing gradually gives your gut time to adapt. A
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LONG TERM SIDE EFFECTD OF METFORMIN Long term problems with Metformin a medication used to control high blood sugar and treat type 2 diabetes. • Overview: Metformin is commonly used to control blood sugar levels in Type 2 diabetes. While generally safe, long-term use can lead to certain side effects. • Relevant Information: Common side effects of metformin include gastrointestinal issues such as nausea, vomiting, diarrhea, stomach ache, loss of appetite, and a metallic taste. A rare but serious
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